EFFECTS OF VENTRAL STRIATAL 6-OHDA LESIONS OR AMPHETAMINE SENSITIZATION ON ETHANOL-CONSUMPTION IN THE RAT

被引：58

作者：

FAHLKE, C

HANSEN, S

ENGEL, JA

HARD, E

机构：

[1] UNIV GOTEBORG,DEPT PSYCHOL,S-40020 GOTHENBURG,SWEDEN

[2] DEPT PHARMACOL,S-41390 GOTHENBURG,SWEDEN

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 47卷 / 02期

关键词：

6-OHDA; DOPAMINE; ETHANOL; AMPHETAMINE; VENTRAL STRIATUM; NUCLEUS ACCUMBENS; SENSITIZATION; ALCOHOL PREFERENCE;

D O I：

10.1016/0091-3057(94)90020-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Female rats with continuous access to water and 6% ethanol were given bilateral ventral striatal 6-OHDA infusions, which induced pronounced striatal depletions of dopamine. The postoperative ethanol consumption of these rats was not significantly affected in comparison to vehicle-infused controls. In a second experiment, female rats received escalating doses of damphetamine over a 5-week period (from 1 to 9 mg/kg/injection). Control females were given saline injections. Following a 3-month drug-free interval, the females were given access to ethanol, the concentration of which was gradually increased from 2% to 12% with weekly intervals. Amphetamine-sensitized rats consumed significantly more alcohol than the saline-treated controls. Taken together, these results suggest that striatal dopaminergic mechanisms, while not necessary for basal ethanol drinking, can facilitate alcohol drinking.

引用

页码：345 / 349

页数：5

共 43 条

[1] FEEDBACK AND FACILITATION IN THE ADRENOCORTICAL SYSTEM - UNMASKING FACILITATION BY PARTIAL INHIBITION OF THE GLUCOCORTICOID RESPONSE TO PRIOR STRESS [J].