ELEVATED SERUM INTERLEUKIN-6 IN POEMS SYNDROME REFLECTS THE ACTIVITY OF THE DISEASE

被引：40

作者：

HITOSHI, S

SUZUKI, K

SAKUTA, M

机构：

[1] Department of Neurology, Institute for Brain Research, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113

[2] Department of Neurology, Tokyo Metropolitan Geriatric Medical Center, Tokyo and the Department of Hematology and Neurology, Japanese Red Cross Medical Center, Tokyo

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 10期

关键词：

INTERLEUKIN-1-BETA; TUMOR NECROSIS FACTOR-ALPHA; PLASMA CELL DYSCRASIA;

D O I：

10.2169/internalmedicine.33.583

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In patients with POEMS syndrome, which often accompanies plasma cell dyscrasia, the roles of interleukin-6 (IL-6) and other acute phase cytokines are unknown. Serum IL-6, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) were measured by the enzyme-linked immunosorbent assay technique in 16 patients with POEMS syndrome and in patients with other neurological diseases (OND) as control. Serum IL-6 was more frequently detected and higher in active POEMS than in stable POEMS or in OND patients. No sample was positive for IL-1beta. TNF-alpha was positive in 3 out of 7 active POEMS patients, but its significance was not definite. Serum IL-6 levels in POEMS patients reflected the disease activity but not the severity of accompanying plasma cell dyscrasia.

引用

页码：583 / 587

页数：5

共 14 条

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