ESTABLISHING A HISTOLOGIC BASIS FOR FALSE-NEGATIVE MAMMOGRAMS

被引:31
作者
HOLLINGSWORTH, AB [1 ]
TAYLOR, LDH [1 ]
RHODES, DC [1 ]
机构
[1] UNIV OKLAHOMA,HLTH SCI CTR,DEPT RADIOL,OKLAHOMA CITY,OK 73190
关键词
D O I
10.1016/S0002-9610(05)80671-3
中图分类号
R61 [外科手术学];
学科分类号
摘要
In order to explore the histology of false-negative mammograms, 264 consecutive patients with breast cancer were retrospectively reviewed until 100 patients with palpable cancers were identified. These patients were imaged by a dedicated mammographer within 6 months prior to biopsy. Nine of the 100 patients had ''negative'' readings originally, with 6 of the 9 still regarded as negative when re-examined after full knowledge of the tumor location. Histologic review of these six tumors showed a diffusely infiltrative pattern in five patients (three with invasive lobular carcinomas and two with multifocal, invasive ductal carcinomas). Although background breast density always serves in a critical relationship with tumor density on film, only one of these six patients showed a severe degree of mammographic breast density. Diffuse histology should be recognized as a principal cause of false-negative mammograms. Since mammography is based solely on anatomic contrasts, diffuse histology could easily prevent the perfection of this modality, calling attention to the need for improved adjunct imaging techniques.
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收藏
页码:643 / 647
页数:5
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