MECHANISMS OF SPLENIC CLEARANCE OF BLOOD-CELLS AND PARTICLES - TOWARDS DEVELOPMENT OF NEW SPLENOTROPIC AGENTS

被引：116

作者：

MOGHIMI, SM

机构：

[1] Department of Pharmaceutical Sciences, University of Nottingham, Nottingham, NG7 2RD, University Park

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1995年 / 17卷 / 01期

关键词：

FILTRATION; MACROPHAGE; SPLEEN MACROPHAGE; SPLENIC BLOOD FLOW PATHWAY; PHAGOCYTOSIS;

D O I：

10.1016/0169-409X(95)00043-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The mammalian spleen is quintessentially a filter of the blood and a pre-eminent reticuloendothelial organ, possessing a large capacity for removing blood cells, infectious microorganisms, particles and macromolecules from the blood. These functions, which are reflected in the unique vascular structure of the spleen, have provided the basis for the development of splenotropic agents for exploitation in both clinical and experimental medicine and are outlined in this overview.

引用

页码：103 / 115

页数：13

共 101 条

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