PML-RAR-ALPHA PCR POSITIVITY IN THE BONE-MARROW OF PATIENTS WITH APL PRECEDES HEMATOLOGICAL RELAPSE BY 2-3 MONTHS

被引:33
作者
KORNINGER, L
KNOBL, P
LACZIKA, K
MUSTAFA, S
QUEHENBERGER, P
SCHWARZINGER, I
LECHNER, K
JAEGER, U
MANNHALTER, C
机构
[1] UNIV VIENNA,DEPT CLIN CHEM & LAB MED,VIENNA,AUSTRIA
[2] UNIV VIENNA,DEPT MED 1,DIV HAEMATOL & HAEMOSTASEOL,VIENNA,AUSTRIA
关键词
APL; PML-RAR-ALPHA; PCR; RELAPSE; COAGULATION PARAMETERS;
D O I
10.1111/j.1365-2141.1994.tb05048.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report the results of serial tests in three patients with hyperleucocytotic AML M3 by haematological methods, coagulation assays and PCR analyses following treatment with ATRA and chemotherapy. All three patients became PCR negative in bone marrow and peripheral blood (sensitivity level 1 in 10(5) cells) after one cycle of ATRA+ chemotherapy. However, they relapsed haematologically 6-9 months after achieving complete haematological remission. The haematological relapse was preceded by PCR positivity in the bone marrow by 3 months. Platelet counts decreased already during CHR, but dropped below normal levels only at the time of relapse. Coagulation parameters were not helpful for early prediction of relapse. Our results demonstrate that PCR analysis in the bone marrow is the best way to monitor patients with APL. However, in hyperleucocytotic patients, PCR negativity does not seem to indicate long-term remission.
引用
收藏
页码:427 / 431
页数:5
相关论文
共 15 条
  • [1] WHAT IS THE BEST TREATMENT FOR ACUTE PROMYELOCYTIC LEUKEMIA
    AVVISATI, G
    PETTI, MC
    MANDELLI, F
    [J]. LEUKEMIA & LYMPHOMA, 1993, 11 : 29 - 35
  • [2] DIAGNOSIS OF ACUTE PROMYELOCYTIC LEUKEMIA BY RT-PCR - DETECTION OF PML-RARA AND RARA-PML FUSION TRANSCRIPTS
    BORROW, J
    GODDARD, AD
    GIBBONS, B
    KATZ, F
    SWIRSKY, D
    FIORETOS, T
    DUBE, I
    WINFIELD, DA
    KINGSTON, J
    HAGEMEIJER, A
    REES, JKH
    LISTER, TA
    SOLOMON, E
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1992, 82 (03) : 529 - 540
  • [3] CASTAIGNE S, 1990, BLOOD, V76, P1704
  • [4] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
  • [5] CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
  • [6] DIVERIO D, 1993, BLOOD, V82, P3556
  • [7] FENAUX P, 1992, BLOOD, V80, P2176
  • [8] LACZIKA K, 1994, LEUKEMIA, V8, P1
  • [9] MOLECULAR EVALUATION OF RESIDUAL DISEASE AS A PREDICTOR OF RELAPSE IN ACUTE PROMYELOCYTIC LEUKEMIA
    LOCOCO, F
    DIVERIO, D
    PANDOLFI, PP
    BIONDI, A
    ROSSI, V
    AVVISATI, G
    RAMBALDI, A
    ARCESE, W
    PETTI, MC
    MELONI, G
    MANDELLI, F
    GRIGNANI, F
    MASERA, G
    BARBUI, T
    PELICCI, PG
    [J]. LANCET, 1992, 340 (8833) : 1437 - 1438
  • [10] DETECTION OF CHIMERIC BCR-ABL GENES IN ACUTE LYMPHOBLASTIC-LEUKEMIA BY THE POLYMERASE CHAIN-REACTION
    MAURER, J
    JANSSEN, JWG
    THIEL, E
    VANDENDEREN, J
    LUDWIG, WD
    AYDEMIR, U
    HEINZE, B
    FONATSCH, C
    HARBOTT, J
    REITER, A
    RIEHM, H
    HOELZER, D
    BARTRAM, CR
    [J]. LANCET, 1991, 337 (8749) : 1055 - 1058