ON ABSOLUTE CONFIGURATION OF 19-HYDROXY-PROSTAGLANDIN B1

被引：19

作者：

HAMBERG, M

机构：

[1] Institutionen for Medicinsk Kemi Kungl, Veterinärhögskolan, Stockholm

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1968年 / 6卷 / 01期

关键词：

D O I：

10.1111/j.1432-1033.1968.tb00431.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

19‐Hydroxy‐prostaglandin B1, isolated from human seminal plasma, was treated with tritiumlabeled acetic anhydride and degraded by oxidation with permanganate in acetone. Tritiumlabeled 3‐acetoxybutanoic acid was isolated from the oxidation product and diluted with unlabeled dl‐3‐acetoxybutanoic acid. The morphine salt of the acid was resolved. These experiments showed that the tritium‐labeled 3‐acetoxybutanoic acid had the d‐configuration and consequently the parent 19‐hydroxy‐prostaglandin B1 has the d‐configuration at C‐19. The configuration at C‐15 is discussed. Copyright © 1968, Wiley Blackwell. All rights reserved

引用

页码：147 / &

共 15 条

[1]

ANGGARD E, 1966, ARK KEMI, V25, P293

[2]

ANGGARD E, PERSONAL COMMUNICATI

[3]

BERGSTROM S, 1963, J BIOL CHEM, V238, P3555

[4] EFFECT OF 8 NEW PROSTAGLANDINS ON HUMAN MYOMETRIUM [J].