CONFIGURATION AND CONFORMAL ANALYSIS OF 2-SUBSTITUTED CYCLOHEPTANOLS

The cis-trans-isomers of 2-substituted cycloheptanols can be distinguished by the different chemical shifts of the proton at the C atom bearing the hydroxyl group. Decoupling experiments show also a significant difference between the coupling constants of the two tertiary protons in the cis- and trans- isomers and give the coupling constants to the adjacent protons. The different NMR spectra are only due to the configuration of the substituents and not to a preferred conformation of the 7-membered ring system. © 1969.