MECHANISMS OF NITRATE TOLERANCE - A REVIEW

被引：17

作者：

KATZ, RJ

机构：

[1] Division of Cardiology, George Washington University Medical Center, Washington, D. C., 20037

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1990年 / 4卷 / 01期

关键词：

drug tolerance; glyceryl trinitrate; isosorhide dinitrate; N-acetylcysteine; nitroglycerin; sulfhydryl; vasodilators;

D O I：

10.1007/BF01857640

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With the increased use of long-acting nitroglycerin preparations, there has been greater recognition of the problem of nitrate tolerance. In recent years extensive research has broadened our understanding of the mechanisms of nitroglycerin action and the mechanisms of drug attenuation. This paper reviews the current state of knowledge regarding nitroglycerin tolerance, with an emphasis on the concepts of cellular and neurohumoral mechanisms of drug attenuation. The discussion includes potential approaches to prevent nitrate tolerance, including the introduction of a nitrate-free interval, or concomitant administration of sulfhydryl donors or neurohumoral blocking agents. © 1990 Kluwer Academic Publishers.

引用

页码：247 / 252

页数：6

共 55 条

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