LITHIUM ADMINISTRATION ANTAGONIZES CHOLINERGIC BEHAVIORAL-EFFECTS IN RODENTS

被引：9

作者：

JANOWSKY, DS

ABRAMS, AA

GROOM, GP

JUDD, LL

CLOPTIN, P

机构：

[1] Department of Psychiatry, University of California at San Diego, School of Medicine, La Jolla, 92093, Ca.

来源：

PSYCHOPHARMACOLOGY | 1979年 / 63卷 / 02期

关键词：

Acetylcholine; Cholinesterase inhibitor; Lithium; Methylphenidate; Physostigmine; Sterotyped behavior;

D O I：

10.1007/BF00429693

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Physostigmine, a centrally acting cholinesterase inhibitor, antagonizes methylphenidate-induced stereotyped gnawing behavior in mice and rats. This effect is significantly attenuated when lithium chloride is concurrently administered, indicating that lithium chloride may antagonize central cholinergic activity. This observation may have theoretical implications for an adrenergic-cholinergic balance hypothesis of affective disorders. © 1979 Springer-Verlag.

引用

页码：147 / 150

页数：4

共 21 条

[1]

ANFRED T, 1968, ACTA PHARMACOL TOXIC, V26, P384

[2] EFFECT OF LITHIUM IONS ON RELEASE OF ACETYLCHOLINE FROM CEREBRAL CORTEX [J].