THE N-SUBSTITUTION OF ALIPHATIC PRIMARY AMINES VIA 1-[(ALKYLAMINO)METHYL]BENZOTRIAZOLES - PREPARATION OF SECONDARY-AMINES

被引：18

作者：

KATRITZKY, AR

NOBLE, G

PILARSKI, B

HARRIS, P

机构：

[1] Department of Chemistry, University of Florida, Gainesville, Florida

来源：

CHEMISCHE BERICHTE | 1990年 / 123卷 / 06期

关键词：

Amines; secondary; Benzotriazole; Grignard reagent; mannich reaction;

D O I：

10.1002/cber.19901230640

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method has been developed for the selective conversion of primary aliphatic amines into unsymmetrical secondary amines by Grignard reaction of 1‐[(alkylamino)methyl]‐benzotriazoles 1. This method employs simple procedure and mild conditions, and is specific in that only monoalkylation of the primary amines results. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

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页码：1443 / 1445

页数：3

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