BIAS DESPITE MASKED ASSESSMENT OF CLINICAL OUTCOMES WHEN AN OUTCOME IS DEFINED AS ONE OF SEVERAL COMPONENT EVENTS

被引:9
作者
WACHOLDER, S
LUBIN, JH
DOSEMECI, M
GAIL, MH
机构
[1] National Cancer Institute, Epidemiology and Biostatistics Program, MD
来源
CONTROLLED CLINICAL TRIALS | 1991年 / 12卷 / 04期
关键词
BLINDED STUDY; DIAGNOSIS; MISCLASSIFICATION; STUDY DESIGN;
D O I
10.1016/0197-2456(91)90006-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Hypothetical examples are presented that show that bias can result from misclassification of clinical outcomes defined as one of several events, even though the assessment of each component event was masked. In one example, the effect of the overall misclassification is to make a treatment that reduces the risk appear to increase it; in another example, misclassification causes the overall treatment effect to appear stronger than it actually is. These anomalies are due to the fact that the misclassification of the overall outcome can be differential, even though the misclassification of the individual components is nondifferential.
引用
收藏
页码:457 / 461
页数:5
相关论文
共 3 条
[1]  
Friedman LM, 1981, FUNDAMENTALS CLIN TR
[2]   MISCLASSIFICATION IN 2 X 2 TABLES [J].
NEWELL, DJ .
BIOMETRICS, 1963, 19 (01) :187-&
[3]  
WACHOLDER S, IN PRESS AM J EPIDEM