SIMPLE SYNTHESIS OF 4-THIOTHYMIDINE, 4-THIOURIDINE AND 6-THIO-2'-DEOXYGUANOSINE

被引：33

作者：

XU, YZ

ZHENG, QG

SWANN, PF

机构：

[1] CRC Nitrosamine-Induced Cancer Research Group Department of Biochemistry and Molecular Biology, London, WC1E 6BT England, University College London Gower St.

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 24期

关键词：

THIONUCLEOSIDES; 4-THIOTHYMIDINE; 4-THIOURIDINE; 6-THIO-2'-DEOXYGUANOSINE; THIATION;

D O I：

10.1016/0040-4039(91)85095-M

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-triazolo-pyrimidine nucleosides and 6-O-(mesitylenesulfonyl)-2'-deoxyguanosine, when treated with thiolacetic acid at room temperature, gave the corresponding 4-thiopyrimidine nucleosides and 6-thio-2'-deoxyguanosine with high yields (86-93%). Possible mechanisms are discussed.

引用

页码：2817 / 2820

页数：4

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