POSTSTATIN, A NEW INHIBITOR OF PROLYL ENDOPEPTIDASE, PRODUCED BY STREPTOMYCES-VIRIDOCHROMOGENES MH534-30F3 .2. STRUCTURE DETERMINATION AND INHIBITORY ACTIVITIES

被引：34

作者：

NAGAI, M

OGAWA, K

MURAOKA, Y

NAGANAWA, H

AOYAGI, T

TAKEUCHI, T

机构：

[1] Institute of Microbial Chemistry, Tokyo 141, 3-14-23 Kamiosaki, Shinagawa-ku

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 09期

关键词：

D O I：

10.7164/antibiotics.44.956

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Poststatin, a new inhibitor of prolyl endopeptidase, has been isolated from the culture broth of Streptomyces viridochromogenes MH534-30F3. The structure of poststatin was defined as L-valyl-L-valyl-3-amino-2-oxovaleryl-D-leucyl-L-valine by analysis of spectral properties and chemical studies of poststatin and its derivatives. The alpha-keto group of postine in poststatin plays the most important role on the inhibitory mechanism.

引用

页码：956 / 961

页数：6

共 5 条

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