THE ONTOGENY OF THE UPTAKE SYSTEMS FOR GLYCINE, GABA AND GLUTAMATE IN SYNAPTIC VESICLES ISOLATED FROM RAT SPINAL-CORD MEDULLA

被引：9

作者：

CHRISTENSEN, H ^{[1
]}

FONNUM, F ^{[1
]}

机构：

[1] NORWEGIAN DEF RES ESTAB,DIV ENVIRONM TOXICOL,N-2007 KJELLER,NORWAY

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1991年 / 64卷 / 1-2期

关键词：

ONTOGENY; SYNAPTIC VESICLE; VESICULAR UPTAKE; SPINAL CORD; MEDULLA; GLYCINE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE;

D O I：

10.1016/0165-3806(91)90219-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synaptic vesicles have been isolated from rat spinal cord-medulla at different postnatal ages, and the ontogeny of the uptake of glycine, gamma-aminobutyric acid (GABA) and glutamate has been investigated. The accumulation of the 3 amino acids increased with increasing time after birth reaching adult level at about postnatal day 30. This developmental increase probably parallels the synaptogenesis and suggests a functional role of the uptake of the amino acids into synaptic vesicles in the nerve terminals. The developmental time course for these vesicular uptake systems was totally different from those of the corresponding plasma membrane uptakes.

引用

页码：155 / 159

页数：5

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