COLCHICINE POISONING - REPORT OF A FATAL CASE WITH BODY-FLUID ANALYSIS BY GC/MS AND HISTOPATHOLOGIC EXAMINATION OF POSTMORTEM TISSUES

被引：46

作者：

CLEVENGER, CV

AUGUST, TF

SHAW, LM

机构：

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 1991年 / 15卷 / 03期

关键词：

D O I：

10.1093/jat/15.3.151

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A suicide caused by oral ingestion of colchicine is reported. Postmortem examination revealed circulating Pelger-Huet polymorphonuclear leukocytes and numerous mitotic and chromatin bodies in tissues with rapid cell turnover. Colchicine was identified by gas chromatography/mass spectrometry (GC/MS) of an organic extract of a urine specimen obtained about 36 h after the patient's original hospitalization. The clinical history and pathology of this rarely encountered intoxication are correlated with previous reports, and the rapid detection of colchicine by GC/MS is discussed.

引用

页码：151 / 154

页数：4

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