PROTEIN-RADICAL ENZYMES

被引：65

作者：

PEDERSEN, JZ

FINAZZIAGRO, A

机构：

[1] TOR VERGATA UNIV ROME,DEPT EXPTL MED,VIA O RAIMONDO,I-00173 ROME,ITALY

[2] TOR VERGATA UNIV ROME,DEPT BIOL,I-00173 ROME,ITALY

来源：

FEBS LETTERS | 1993年 / 325卷 / 1-2期

关键词：

PROTEIN-RADICAL ENZYME; PYRROLOQUINOLINE QUINONE; TRIOXYPHENYLALANINE; TRYPTOPHAN TRYPTOPHYL QUINONE; FREE RADICAL; ESR;

D O I：

10.1016/0014-5793(93)81412-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein-radical enzymes use a free radical located on an intrinsic amino acid residue as a cofactor. The amino acid involved can be a tyrosine (ribonucleotide reductase, photosystem II, prostaglandin H synthase), a modified tyrosine (amine oxidase, galactose oxidase), a tryptophan (cytochrome c peroxidase), a modified tryptophan (methylamine dehydrogenase) or a glycine (ribonucleotide reductase, pyruvate formate lyase). The mechanistic role of these radicals appears to be that of a one-electron gate, allowing the separation of single reducing equivalents in time and space.

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页码：53 / 58

页数：6

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