STRUCTURE AND SYNTHESIS OF CLAUSENAQUINONE-A - A NOVEL CARBAZOLEQUINONE ALKALOID AND BIOACTIVE PRINCIPLE FROM CLAUSENA-EXCAVATA

被引：25

作者：

WU, TS ^{[1
]}

HUANG, SC ^{[1
]}

WU, PL ^{[1
]}

LEE, KH ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(01)80397-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new carbazolequinone alkaloid, clausenaquinone-A, has been isolated from the stem bark of Clausena excavata. The structure has been established from spectral data and total synthesis. Clausenaquinone-A shows potent inhibitory activity of the rabbit platelet aggregation as well as cytotoxicity in HCT-I, RPMI-7951, and TE671 tumor cells.

引用

页码：2395 / 2398

页数：4