LUNG MORPHOLOGY IN RATS TREATED WITH HEXAMETHYLPHOSPHORAMIDE

Severe bronchiectasis and bronchopneumonia with areas of squamous metaplasia and fibrosis were observed in the lungs of rats given hempa in their diet at a dietary rate of 2000 ppm (127-106 mg/kg/day) over a period of 52-72 days. Dimethylamine is a metabolite of hempa, but only a trace of it is excreted by way of the lungs following dosage of hempa sufficient to injure the lungs. This trace of dimethylamine is not sufficient to explain the observed lung disease, which is probably the result of hempa itself. © 1968.