POLYAMINES INHIBIT DNA METHYLATION INVITRO

被引:16
作者
COX, R [1 ]
机构
[1] UNIV TENNESSEE,CTR HLTH SCI,DEPT BIOCHEM,MEMPHIS,TN 38104
关键词
D O I
10.1016/0006-291X(79)91754-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA methylase from rat liver differs from RNA methylase in response to polyamines, being inhibited rather than stimulated. With methyl-deficient DNA from rat liver as substrate, the DNA methylase is inhibited 97%, 59% and 42% respectively, by spermine, spermidine and putrescine at 1 mM concentration. © 1979.
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页码:594 / 598
页数:5
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