RELAXATION OF INTESTINAL BLADDERS BY INTRAVESICAL OXYBUTYNIN CHLORIDE

被引：30

作者：

MOHLER, JL

机构：

[1] Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland

来源：

NEUROUROLOGY AND URODYNAMICS | 1990年 / 9卷 / 02期

关键词：

bladder augmentation; incontinence; topical oxybutynin chloride;

D O I：

10.1002/nau.1930090211

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Incontinence is a frequent complication of continent urinary diversions and neurogenic bladder augmentations constructed from intestinal segments. Oxybutynin chloride was delivered intravesically and orally to six beagles 9 months after bladders were replaced by tubularized ileum (in three dogs) or sigmorectum (in three dogs). Intravesical oxybutynin produced greater bladder relaxation by urodynamic criteria. Measured oxybutynin chloride concentrations suggested that high tissue levels were achieved at low systemic levels. In two human patients with ileocecal urinary diversions, intravesical oxybutynin chloride decreased bladder pressure and decreased the number and magnitude of superimposed contractions. Intravesical application of oxybutynin chloride may produce local drug levels unachievable by oral administration and may better treat incontinence in patients who intermittently catheterize intestinal bladders or intestinally augmented neurogenic bladders. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：179 / 187

页数：9

共 8 条

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