GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC CHARACTERIZATION OF SOME NOVEL HYDROXYEICOSATETRAENOIC ACIDS FORMED ON INCUBATION OF ARACHIDONIC-ACID WITH MICROSOMES FROM INDUCED RAT LIVERS

被引:21
作者
CLARE, RA [1 ]
HUANG, S [1 ]
DOIG, MV [1 ]
GIBSON, GG [1 ]
机构
[1] UNIV SURREY,DEPT BIOCHEM,GUILDFORD GU2 5XH,SURREY,ENGLAND
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 562卷 / 1-2期
基金
英国惠康基金;
关键词
D O I
10.1016/0378-4347(91)80581-V
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The biotransformation of arachidonic acid by rat liver microsomes from both control animals and animals pretreated with known inducers of cytochrome P-450 isoenzymes has been studied using a combination of reversed- and normal-phase high-performance liquid chromatography and combined gas chromatography-electron-impact mass spectrometry. The metabolite profiles observed were found to be dependent upon the inducing agent. Five metabolites were identified, namely 16-, 17-, 18-, 19- and 20-hydroxylated arachidonic acids. Of these the 16- and 17-isomers have not been reported as products of arachidonic acid metabolism by any biological system and the 18-isomer has not been reported as a product of liver metabolism.
引用
收藏
页码:237 / 247
页数:11
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