EFFICIENT SYNTHESES OF ENANTIOMERICALLY PURE L-ALLOTHREONINE AND D-ALLOTHREONINE AND (S)-ISOSERINE AND (R)-ISOSERINE

被引：43

作者：

PONS, D

SAVIGNAC, M

GENET, JP

机构：

[1] Laboratoire de Synthèse Organique Associé au C.N.R.S., Ecole Nationale Supérieure de Chimie de Paris, 75231 PARIS, 11, rue P. et M. Curie

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)97795-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both enantiomers of (S) 1 and (R) 2 isoserine as well (D) 3 and (L) 4 allothreonine are prepared optically pure in three steps by asymmetric Sharpless epoxidation of crotyl and allylic alcohols into 7- 10 followed by an improved RuCl3/NaIO4/water oxidation procedure to low molecular weight glycidic acids 11 - 14 and epoxide opening by ammonia with (20 - 33%) overall yields. © 1990.

引用

页码：5023 / 5026

页数：4

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