EFFECT OF PGE2 ON INTERLEUKIN-1 AND SUPEROXIDE RELEASE FROM PRIMARY-CULTURED HUMAN HEPATIC MACROPHAGES

被引：9

作者：

FUNAKI, N

ARII, S

ADACHI, Y

HIGASHITUJI, H

FUJITA, S

FURUTANI, M

MISE, M

ISHIGURO, S

KITAO, T

TANAKA, J

TOBE, T

机构：

[1] First Department of Surgery, Faculty of Medicine Kyoto University, Sakyo-ku, Kyoto, 606

来源：

LIFE SCIENCES | 1992年 / 51卷 / 17期

关键词：

D O I：

10.1016/0024-3205(92)90633-Z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In order to learn more about how human hepatic macrophages function, we analyzed the effect of exogeneous PGE2 on the amounts of interleukin-1 (IL-1) and superoxide (O2-) released from primary-cultured human hepatic macrophages (HHM-PHI). When endogenous PGE2 production was blocked by indomethacin, exogenous PGE2 reduced IL-1 release from HHM-PHI in a dose-dependent manner, whereas it tended to increase O2- release from HHM-PHI. These results may suggest the probable contribution of PGE2 in regulating HHM-PHI mediator release in vivo.

引用

页码：1339 / 1346

页数：8

共 30 条

[1]

AIDA Y, 1990, J IMMUNOL, V145, P3017

[2] DEPRESSED FUNCTION OF KUPFFER CELLS IN RATS WITH CCL4-INDUCED LIVER-CIRRHOSIS [J].