SEXUAL DIMORPHISM OF STRESS-INDUCED CHANGES IN RENAL PERIPHERAL BENZODIAZEPINE RECEPTORS IN RAT

被引：14

作者：

DRUGAN, RC

HOLMES, PV

STRINGER, AP

机构：

[1] Schrier Research Laboratory Department, Psychology Brown University Providence

来源：

NEUROPHARMACOLOGY | 1991年 / 30卷 / 04期

关键词：

STRESS; PERIPHERAL BENZODIAZEPINE RECEPTOR; KIDNEY; MALE; FEMALE; RAT;

D O I：

10.1016/0028-3908(91)90069-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult male and female rats were exposed to either inescapable shock or no treatment. In vitro [H-3]Ro 5-4864 (4'-chlorodiazepam) binding (1 nM) to peripheral benzodiazepine receptors (PRB) in both CNS and peripheral tissues indicated no gender differences in olfactory bulb, heart, lung or adrenal gland but a significant effect was observed in renal tissue. Female rats showed an attenuated stress-induced reduction (23%) in PBR in comparison to males (55%). This difference was shown to be an alteration of Bmax and not kD by Scatchard analysis. These data are the first demonstration of a sexual dimorphism in environmentally-induced alterations in PBR.

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收藏

页码：413 / 416

页数：4

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