EFFECTS OF CALCIUM-CHANNEL BLOCKERS ON FORMALIN-INDUCED NOCICEPTION AND INFLAMMATION IN RATS

被引：33

作者：

GURDAL, H ^{[1
]}

SARA, Y ^{[1
]}

TULUNAY, FC ^{[1
]}

机构：

[1] UNIV ANKARA,SCH MED,DEPT PHARMACOL,ANKARA,TURKEY

来源：

PHARMACOLOGY | 1992年 / 44卷 / 05期

关键词：

NOCICEPTION; INFLAMMATION; FORMALIN TEST; RAT PAW; CALCIUM CHANNEL BLOCKERS;

D O I：

10.1159/000138932

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The possible anti-inflammatory and antinociceptive effects of nitrendipine, nicardipine, diltiazem and verapamil were examined with formalin test in the rat paw. Pretreatment with these calcium channel blockers 1 h before formalin injection diminished formalin-induced inflammatory changes and nociceptive responses. Formalin-induced nociceptive responses were inhibited 20-90% by the calcium channel blockers. Nitrendipine and nicardipine were found to be highly effective in inhibiting the inflammatory changes, whereas the effects of verapamil and diltiazem were partial. Administration of naloxone affected neither the inflammatory changes and nociceptive responses induced by formalin nor the anti-inflammatory and antinociceptive effects of the calcium channel blockers. The results suggest the possible anti-inflammatory and naloxone-insensitive antinociceptive properties of calcium channel blockers.

引用

页码：290 / 296

页数：7

共 15 条

[1]

ANDERSON JR, 1976, MUIRS TXB PATHOLOGY, P34

[2] EFFECTS OF ELEVATED CALCIUM AND CALCIUM-ANTAGONISTS ON 6,7-BENZOMORPHAN-INDUCED ANALGESIA [J].