HALOPERIDOL TREATMENT INCREASES D2 DOPAMINE RECEPTOR PROTEIN INDEPENDENTLY OF RNA LEVELS IN MICE

被引：31

作者：

GOSS, JR ^{[1
]}

KELLY, AB ^{[1
]}

JOHNSON, SA ^{[1
]}

MORGAN, DG ^{[1
]}

机构：

[1] UNIV SO CALIF, DEPT BIOL SCI, LOS ANGELES, CA 90089 USA

来源：

LIFE SCIENCES | 1991年 / 48卷 / 10期

关键词：

D O I：

10.1016/0024-3205(91)90367-K

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Haloperidol, administered to mice in their drinking water, produced a 21% increase in striatal D2 dopamine receptor density after seven days of continuous exposure. The steady-state D2 receptor RNA prevalence was unaffected by this treatment, yet the RNA coding for preproenkephalin was elevated, as expected. These data indicate that the homologous up-regulation of dopamine receptor density by antipsychotic drugs proceeds by mechanisms other than changes in RNA abundance.

引用

页码：1015 / 1022

页数：8

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