DIRECT SEPARATION OF THE ENANTIOMERS OF PROPAFENONE, DIPRAFENONE AND THEIR MAJOR METABOLITES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON MODIFIED CELLULOSE AND AMYLOSE CHIRAL STATIONARY PHASES

被引：34

作者：

HOLLENHORST, T ^{[1
]}

BLASCHKE, G ^{[1
]}

机构：

[1] UNIV MUNSTER,INST PHARMACEUT CHEM,HITTORFSTR 58-62,W-4400 MUNSTER,GERMANY

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 585卷 / 02期

关键词：

D O I：

10.1016/0021-9673(91)85097-Y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The enantiomers of propafenone, diprafenone and their major metabolites, N-desalkylpropafenone, 5-hydroxypropafenone and 5-hydroxydiprafenone, were separated on a cellulose tris-3,5-dimethylphenylcarbamate column (Chiralcel OD) and an amylose tris-3,5-dimethylphenylcarbamate column (Chiralpak AD).

引用

页码：329 / 332

页数：4

共 6 条

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[2] KROEMER H, 1989, ARZNEIMITTELTHERAPIE, V7, P4
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KROEMER, HK
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RODEN, DM
[J]. CIRCULATION, 1989, 79 (05) : 1068 - 1076
[4] CHROMATOGRAPHIC RESOLUTION .12. OPTICAL RESOLUTION OF BETA-BLOCKERS BY HPLC ON CELLULOSE TRIPHENYLCARBAMATE DERIVATIVES
OKAMOTO, Y
KAWASHIMA, M
ABURATANI, R
HATADA, K
NISHIYAMA, T
MASUDA, M
[J]. CHEMISTRY LETTERS, 1986, (07) : 1237 - 1240
[5] WALTHER B, 1985, THESIS U MUNSTER MUN
[6] Wecker D., COMMUNICATION

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