ACTIVIN AND INHIBIN IN THE HUMAN ADRENAL-GLAND - REGULATION AND DIFFERENTIAL-EFFECTS IN FETAL AND ADULT-CELLS

被引:112
作者
SPENCER, SJ [1 ]
RABINOVICI, J [1 ]
MESIANO, S [1 ]
GOLDSMITH, PC [1 ]
JAFFE, RB [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO, DEPT OBSTET GYNECOL & REPROD SCI, CTR REPROD ENDOCRINOL, SAN FRANCISCO, CA 94143 USA
关键词
ADRENAL DEVELOPMENT; DIFFERENTIATION; INHIBIN; CORTISOL;
D O I
10.1172/JCI115827
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Recent experimental data have revealed that activins and inhibins exert pivotal effects on development. As part of our studies on growth and differentiation of the human fetal adrenal gland, we examined the subunit localization, as well as the mitogenic and steroidogenic actions of activin and inhibin in human fetal and adult adrenals. All three activin and inhibin subunit proteins (alpha, beta-A, and beta-B) were detected in the fetal and adult adrenal cortex. Immunoreactive activin-A dimer was demonstrated in midgestation fetal and neonatal adrenals. ACTH1-24-stimulated fetal adrenal cell expression of alpha and beta-A subunit messenger RNA. In addition, ACTH elicited a rise in levels of immunoreactive a subunit secreted by fetal and adult adrenal cells. Human recombinant activin-A inhibited mitogenesis and enhanced ACTH-stimulated cortisol secretion by cultured fetal zone cells, but not definitive zone or adult adrenal cells. Recombinant inhibin-A had no apparent mitogenic or steroidogenic effects. Thus, activin selectively suppressed fetal zone proliferation and enhanced the ACTH-induced shift in the cortisol/dehydroepiandrosterone sulfate ratio of fetal zone steroid production. These data indicate that activin-A may be an autocrine or paracrine factor regulated by ACTH, involved in modulating growth and differentiated function of the human fetal adrenal gland.
引用
收藏
页码:142 / 149
页数:8
相关论文
共 38 条
[1]   ACTIVIN-A MODULATES GROWTH-HORMONE SECRETION FROM CULTURES OF RAT ANTERIOR-PITUITARY-CELLS [J].
BILEZIKJIAN, LM ;
CORRIGAN, AZ ;
VALE, W .
ENDOCRINOLOGY, 1990, 126 (05) :2369-2376
[2]   SELECTIVE AND INDIRECT MODULATION OF HUMAN MULTIPOTENTIAL AND ERYTHROID HEMATOPOIETIC PROGENITOR-CELL PROLIFERATION BY RECOMBINANT HUMAN ACTIVIN AND INHIBIN [J].
BROXMEYER, HE ;
LU, L ;
COOPER, S ;
SCHWALL, RH ;
MASON, AJ ;
NIKOLICS, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9052-9056
[3]   ALPHA-INHIBIN GENE-EXPRESSION OCCURS IN THE OVINE ADRENAL-CORTEX, AND IS REGULATED BY ADRENOCORTICOTROPIN [J].
CRAWFORD, RJ ;
HAMMOND, VE ;
EVANS, BA ;
COGHLAN, JP ;
HARALAMBIDIS, J ;
HUDSON, B ;
PENSCHOW, JD ;
RICHARDS, RI ;
TREGEAR, GW .
MOLECULAR ENDOCRINOLOGY, 1987, 1 (10) :699-706
[4]   CONTROL OF PROLIFERATION OF HUMAN-FETAL ADRENAL-CELLS INVITRO [J].
CRICKARD, K ;
ILL, CR ;
JAFFE, RB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (04) :790-796
[5]   ANALYSIS OF THE 5'-FLANKING REGIONS OF RAT INHIBIN ALPHA-B-SUBUNIT AND BETA-B-SUBUNIT GENES SUGGESTS 2 DIFFERENT REGULATORY MECHANISMS [J].
FENG, ZM ;
LI, YP ;
CHEN, CLC .
MOLECULAR ENDOCRINOLOGY, 1989, 3 (12) :1914-1925
[6]  
FINDLAY JK, 1990, REPROD FERT DEVELOP, V2, P205, DOI 10.1071/RD9900205
[7]   HETERODIMERS AND HOMODIMERS OF INHIBIN SUBUNITS HAVE DIFFERENT PARACRINE ACTION IN THE MODULATION OF LUTEINIZING HORMONE-STIMULATED ANDROGEN BIOSYNTHESIS [J].
HSUEH, AJW ;
DAHL, KD ;
VAUGHAN, J ;
TUCKER, E ;
RIVIER, J ;
BARDIN, CW ;
VALE, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (14) :5082-5086
[8]   A RADIOIMMUNOASSAY FOR DEHYDROEPIANDROSTERONE SULFATE IN THE CIRCULATION OF RHESUS-MONKEYS [J].
KORITNIK, DR ;
LAHERTY, RF ;
ROTTEN, D ;
JAFFE, RB .
STEROIDS, 1983, 42 (06) :653-667
[9]   ACTIVIN STIMULATION OF INHIBIN SECRETION AND MESSENGER-RNA LEVELS IN CULTURED GRANULOSA-CELLS [J].
LAPOLT, PS ;
SOTO, D ;
SU, JG ;
CAMPEN, CA ;
VAUGHAN, J ;
VALE, W ;
HSUEH, AJW .
MOLECULAR ENDOCRINOLOGY, 1989, 3 (10) :1666-1673
[10]   A HOMODIMER OF THE BETA-SUBUNITS OF INHIBIN A STIMULATES THE SECRETION OF PITUITARY FOLLICLE-STIMULATING-HORMONE [J].
LING, N ;
YING, SY ;
UENO, N ;
SHIMASAKI, S ;
ESCH, F ;
HOTTA, M ;
GUILLEMIN, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 138 (03) :1129-1137