CHOLESTATIC HEPATITIS FOLLOWING FLUTAMIDE

被引：20

作者：

ROSMAN, AS

FRISSORARODEO, C

MARSHALL, AT

REITER, BP

PARONETTO, F

机构：

[1] MT SINAI SCH MED,BRONX,NY 10468

[2] VET ADM MED CTR,RADIOL SERV,BRONX,NY 10468

[3] VET ADM MED CTR,PATHOL & LAB MED SERV,BRONX,NY 10468

[4] VET ADM MED CTR,MED SERV,BRONX,NY 10468

来源：

DIGESTIVE DISEASES AND SCIENCES | 1993年 / 38卷 / 09期

关键词：

FLUTAMIDE; JAUNDICE; CHOLESTASIS; HEPATITIS; LIVER INJURY;

D O I：

10.1007/BF01303188

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Previous reports have indicated that administration of flutamide-a nonsteroidal antiandrogen drug-may induce hepatic toxicity. However, cholestatic hepatitis following flutamide is a rare event. This case report describes a 72-year-old male with metastatic adenocarcinoma of the prostate who underwent bilateral orchiectomy and treatment with flutamide. After seven weeks he developed jaundice and elevated AST and ALT levels. A liver biopsy showed cholestatic hepatitis without signs of biliary obstruction. The patient's clinical symptoms and elevated bilirubin resolved after the flutamide was discontinued. Monitoring of serum liver enzyme tests is advocated during flutamide administration to identify drug-induced liver injury. © 1993 Plenum Publishing Corporation.

引用

页码：1756 / 1759

页数：4

共 7 条

[1] FLUTAMIDE-RELATED FULMINANT HEPATIC-FAILURE [J].