DIASTEREOSELECTIVE BIS-ALKYLATION OF CHIRAL NON-RACEMIC ALPHA,BETA-UNSATURATED GAMMA-LACTAMS

被引：43

作者：

BAUSSANNE, I ^{[1
]}

CHIARONI, A ^{[1
]}

HUSSON, HP ^{[1
]}

RICHE, C ^{[1
]}

ROYER, J ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBSTANCES NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)76705-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new chiral non-racemic gamma-lactam 1 easily prepared in one step from (R)-(-)-phenylglycinol was bis-alkylated alpha to the carbonyl function in very high to complete diastereoselectivity. The stereochemistry at the so-formed chiral quaternary center was ascertained through an X-ray crystallographic study.

引用

页码：3931 / 3934

页数：4

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