ENHANCEMENT OF SYSTEMIC AND MUCOSAL IMMUNE-RESPONSES FOLLOWING ORAL-ADMINISTRATION OF LIPOSOMES

被引:26
作者
FUJII, Y
ARAMAKI, Y
HARA, T
YACHI, K
KIKUCHI, H
TSUCHIYA, S
机构
[1] TOKYO COLL PHARM, 1432-1 HORINOUCHI, HACHIOJI, TOKYO 19203, JAPAN
[2] DAIICHI PHARMACEUT CO LTD, TOKYO, JAPAN
关键词
LIPOSOME; ORAL ADMINISTRATION; MUCOSAL IMMUNITY; IGA; VACCINE;
D O I
10.1016/0165-2478(93)90070-I
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effects of liposomes on the systemic and mucosal immune response were investigated using bovine serum albumin (BSA) in BALB/c mice. Following three oral administrations of varied formulations at 1-week intervals, serum BSA-specific IgG levels were increased significantly by BSA encapsulated in liposomes and moderately by a mixture of liposomes and BSA. Serum and salivary BSA-specific IgA levels were elevated by BSA-encapsulating liposomes only. Liposomes thus activate not only the systemic immune response but also the mucosal immune response following their oral administration. However, no increase in salivary IgA levels was observed by intraperitoneal or subcutaneous injection of BSA-encapsulating liposomes. The production of IgA is closely related to the oral administration of liposomes encapsulating antigens. Liposomes thus function as carriers of oral vaccines against various infections of the mucosal surface.
引用
收藏
页码:65 / 70
页数:6
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