TOBACCO SMOKING IMPAIRS THE LOCAL IMMUNOSURVEILLANCE IN THE UTERINE CERVIX - AN IMMUNOHISTOCHEMICAL STUDY

被引：75

作者：

POPPE, WAJ

IDE, PS

DRIJKONINGEN, MPG

LAUWERYNS, JM

VANASSCHE, FA

机构：

[1] KATHOLIEKE UNIV LEUVEN,DEPT OBSTET & GYNECOL,LOUVAIN,BELGIUM

[2] KATHOLIEKE UNIV LEUVEN,DEPT PATHOL,LOUVAIN,BELGIUM

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1995年 / 39卷 / 01期

关键词：

CERVIX; SMOKING; LANGERHANS CELLS; LYMPHOCYTES; IMMUNOSTAINING;

D O I：

10.1159/000292372

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cervix. This suggests a local impairment of cell-mediated immunity by smoking. This immunosuppressive effect could support the concept that smoking is an independent risk factor for cervical neoplasia.

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页码：34 / 38

页数：5

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