SURFACE-ENHANCED RAMAN GENE PROBES

被引：219

作者：

VO-DINH, T

HOUCK, K

STOKES, DL

机构：

[1] Advanced Monitoring Development Group, Health Sciences Research Division, Oak Ridge National Laboratory, Oak Ridge

来源：

ANALYTICAL CHEMISTRY | 1994年 / 66卷 / 20期

关键词：

D O I：

10.1021/ac00092a014

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report for the first time a new type of DNA gene probe based on surface-enhanced Raman scattering (SERS) label detection. The surface-enhanced Raman gene (SERG) probes do not require the use of radioactive labels and have great potential to provide both sensitivity and selectivity. The SERG probe can be used to detect DNA biotargets (e.g., gene sequences, bacteria, viral DNA fragments) via hybridization to DNA sequences complementary to that probe. The analytical figures of merit and its applications in environmental and biomedical areas are discussed.

引用

页码：3379 / 3383

页数：5

共 22 条

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