Diabetic vascular hypertrophy and albuminuria: Effect of angiotensin converting enzyme inhibition

被引：9

作者：

Allen, TJ ^{[1
]}

Hulthen, UL ^{[1
]}

Rumble, JR ^{[1
]}

Jasik, M ^{[1
]}

Cooper, ME ^{[1
]}

机构：

[1] UNIV MELBOURNE,AUSTIN & HEIDELBERG REPATRIAT HOSP,DEPT MED,HEIDELBERG,VIC,AUSTRALIA

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 1995年 / 9卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/1056-8727(95)80031-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The role of angiotensin-converting enzyme (ACE) inhibition with ramipril on mesenteric vascular hypertrophy and urinary albumin excretion was explored in a normotensive model of experimental diabetes. Serial measurements of albuminuria were performed in Sprague-Dawley control, diabetic rats, and diabetic rats treated with ramipril. Over 24 weeks, urinary albumin excretion showed a continuous rise in the untreated diabetic rats. Ramipril prevented the increase in albuminuria over the whole study period. After 6 months, animals were perfused with glutaraldehyde and sacrificed for measurement of mesenteric vessel wall/lumen ratio and kidney weight, Diabetes was associated with increased mesenteric wall/lumen ratio and kidney weight. ACE inhibition, despite no effect on glycemic control, attenuated mesenteric vascular hypertrophy but did not decrease kidney weight. In addition to the well-described renoprotective effects of ACE inhibition in diabetes, this class of agents may have a favorable effect on diabetic vascular disease.

引用

页码：318 / 322

页数：5

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