HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC ASSAY OF FOLIC-ACID - COLLABORATIVE STUDY

被引：6

作者：

MCSHARRY, WO

MAHN, FP

机构：

[1] Quality Control Department, Hoffmann-La Roche, Inc., Nutlev, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Folic acid—high‐pressure liquid chromatographic analysis in prepared samples; collaborative study; High‐pressure liquid chromatography—analysis; folic acid in prepared samples; collaborative study a Vitamins—folic acid; high‐pressure liquid chromatographic analysis in prepared samples;

D O I：

10.1002/jps.2600680233

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A collaborative study of the USP high‐pressure liquid chromatographic assay for folic acid was performed. Two samples were analyzed in duplicate by 14 participating laboratories. Relative standard deviations for a single determination (RSDS) ranged from ±0.40 to ±2.39%. Based on an analysis of variance, it was concluded that the method of peak measurement was a major determinant of reproducibilily and that graphical measurement was associated with a high standard deviation. Adequate resolution was obtained using a variety of columns and operating conditions. The interlaboratory RSDS was ±1.8%. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：241 / 243

页数：3