SUBSTANCE-P IS RELEASED FROM THE ENDOTHELIUM OF NORMAL AND CAPSAICIN-TREATED RAT HINDLIMB VASCULATURE, INVIVO, BY INCREASED FLOW

被引：94

作者：

RALEVIC, V

MILNER, P

HUDLICKA, O

KRISTEK, F

BURNSTOCK, G

机构：

[1] UNIV LONDON UNIV COLL, DEPT ANAT & DEV BIOL, GOWER ST, LONDON WC1E 6BT, ENGLAND

[2] UNIV LONDON UNIV COLL, CTR NEUROSCI, LONDON WC1E 6BT, ENGLAND

来源：

CIRCULATION RESEARCH | 1990年 / 66卷 / 05期

基金：

英国惠康基金;

关键词：

capsaicin; increased flow; substance P; vascular endothelial cells;

D O I：

10.1161/01.RES.66.5.1178

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The rat hind-limb vasculature releases substance P when subjected to a rapid increase in flow through the vascular bed. This release also occurs during high flow after rats have been capsaicinized, when loss of substance P-containing nerve fibers was verified by immunohistochemistry. Air treatment, a procedrue shown by transmission electron microscopy to have removed endothelial cells from the arteries but not arterioles or capillaries of the hind-limb preparations, eliminated this release. Thus, the substance P released is unlikely to arise from perivascular nerves but rather from arterial endothelial cells.

引用

页码：1178 / 1183

页数：6

共 27 条

[1] VASODILATATION BY ACETYLCHOLINE IS ENDOTHELIUM-DEPENDENT - A STUDY BY SONOMICROMETRY IN CANINE FEMORAL-ARTERY INVIVO [J].