DAILY COCAINE TREATMENT PRODUCES A PERSISTENT REDUCTION OF [H-3] DOPAMINE UPTAKE INVITRO IN RAT NUCLEUS-ACCUMBENS BUT NOT IN STRIATUM

被引：110

作者：

IZENWASSER, S

COX, BM

机构：

[1] Department of Pharmacology, Uniformed Services University, Bethesda

来源：

BRAIN RESEARCH | 1990年 / 531卷 / 1-2期

关键词：

Cocaine; Dopamine transport; Dopamine uptake; Nucleus accumbens; Striatum;

D O I：

10.1016/0006-8993(90)90797-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Daily administration of cocaine (15 mg/kg i.p. × 3 days) led to a decrease in the total amount of 15 nM [3H]dopamine uptake in rat nucleus accumbens with no changes in uptake in the striatum when tested 24 h after the last injection. There was an increase in the Km for dopamine uptake in the nucleus accumbens of cocaine-treated rats, with no change in the Vmax. Furthermore, cocaine was a more potent inhibitor of [3H]dopamine uptake in vitro in the nucleus accumbens of rats treated with cocaine than in those which had received saline. © 1990.

引用

页码：338 / 341

页数：4

共 18 条

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