AUGMENTATION OF SPECIFIC IMMUNE-RESPONSE AGAINST A SYNGENEIC SV40-INDUCED SARCOMA IN MICE BY DEPLETION OF SUPPRESSOR T-CELLS WITH CYCLOPHOSPHAMIDE

被引:67
作者
GLASER, M
机构
[1] Department of Biochemistry, The George Washington University Medical Center, Washington, DC 20037
关键词
D O I
10.1016/0008-8749(79)90128-X
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
When cyclophosphamide was administered to mice before immunization with syngeneic SV40-transformed cells, the specific immune response elicited, as was measured by the tumor cell neutralization assay with a syngeneic SV40-induced sarcoma, was stronger and lasted longer as compared to the response generated in non-cyclophosphamide-treated mice. The augmentation effect of the drug was dependent on cyclophosphamide concentration, being optimal at 100 mg/kg, and on the time of drug administration in relation to antigen immunization, being optimal at 2-4 days before antigen administration. Transfer of T cells from normal syngeneic mice to drug-treated animals abolished the cyclophosphamide-induced augmentation of immune response. These results implied that cyclophosphamide-sensitive T cells suppressed the in vivo generation of specific effector T cells against SV40-induced sarcoma. © 1979.
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页码:339 / 345
页数:7
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