PROSTATE - AN EXTRAPITUITARY SOURCE OF FOLLICLE-STIMULATING-HORMONE (FSH) - OCCURRENCE, LOCALIZATION, AND DENOVO BIOSYNTHESIS AND ITS HORMONAL MODULATION IN PRIMATES AND RODENTS

被引：33

作者：

GARDE, SV ^{[1
]}

SHETH, AR ^{[1
]}

SHAH, MG ^{[1
]}

KULKARNI, SA ^{[1
]}

机构：

[1] INDIAN COUNCIL MED RES, INST RES REPROD, JEHANGIR MERWANJI ST, BOMBAY 400012, INDIA

来源：

PROSTATE | 1991年 / 18卷 / 04期

关键词：

BENIGN PROSTATIC HYPERPLASIA; PROSTATE CANCER; CASTRATION; IMMUNOCYTOCHEMISTRY;

D O I：

10.1002/pros.2990180402

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A comparative study on the immunocytochemical localization, de novo biosynthesis, and hormonal modulation of follicle-stimulating hormone (FSH) was carried out in the prostates of man, monkey, dog, guinea pig, hamster, rat, and mouse. FSH was localized in the cytoplasm of the prostatic epithelial cells. In some specimens, staining was also observed in the nucleus. Both pituitary as well as prostatic FSH were coeluted on a Sephadex G-100 column and high-performance liquid chromatography (HPLC) indicating physicochemical similarities of FSH in both the tissues. Surprisingly, the modulation of pituitary and prostatic FSH by inhibin and its related peptides were comparable. The intensity and grandularity of FSH staining was stronger in the case of benign prostatic hyperplasia as compared with normal prostatic specimens. In view of the well-known effects of FSH on the cellular growth, differentiation, and function of gonadal tissues, a similar role for FSH in pathophysiology of prostate is postulated.

引用

页码：271 / 287

页数：17

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