CONSTRUCTION OF AN FK-506 ANALOG FROM RAPAMYCIN-DERIVED MATERIALS

被引：18

作者：

GOULET, MT

HODKEY, DW

机构：

[1] Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 36期

关键词：

FK-506; RAPAMYCIN; IMMUNOSUPPRESSANT; SEMISYNTHESIS; MACROLACTONIZATION;

D O I：

10.1016/S0040-4039(00)92266-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fragments derived from the degradation of rapamycin have been reassembled to form a tricarbonyl containing macrocycle similar in structure to FK-506.

引用

页码：4627 / 4630

页数：4

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