LONG-CHAIN TRIGLYCERIDES REDUCE THE EFFICACY OF ENTERAL FEEDS IN PATIENTS WITH ACTIVE CROHNS-DISEASE

被引：93

作者：

MIDDLETON, SJ

RUCKER, JT

KIRBY, GA

RIORDAN, AM

HUNTER, JO

机构：

[1] Department of Gastroenterology, Addenbrooke's Hospital, Cambridge, CB2 2QQ, Hills Road

来源：

CLINICAL NUTRITION | 1995年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0261-5614(95)80004-2

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Elemental diets are effective treatments for active Crohn's disease. To determine which dietary constituents are of therapeutic importance, the effectiveness of four separate feeds was related to their compositions, and the findings substantiated by meta-analysis of previous dietary studies. 76 patients with active Crohn's disease were recruited. 17 were randomised to an amino-acid based elemental diet (E028), 22 to E028 with added long-chain triglyceride (E028 LCT), 18 to a semi-elemental, peptide based diet (Pepdite 2+) and 19 received E028 with added medium-chain triglyceride (E028 MCT). Disease activity fell in all groups and remission rate was negatively correlated with the amount of energy derived from LCT (r = -0.97, p = 0.016). Inflammatory indices fell in the groups (E028 + E028 MCT) containing least LCT. No other dietary constituents correlated with remission rate. A meta-analysis of published studies confirmed a negative correlation between remission rate and LCT (r = -0.63, p = 0.006) but not other constituents. The association between dietary LCT and remission rate may have pathogenic significance and allow the development of more effective enteral feeds.

引用

页码：229 / 236

页数：8

共 27 条

[1] O'Morain, Segal, Levi, Elemental diets in treatment of acute Crohn's disease, BMJ, 281, pp. 1173-1175, (1980)
[2] O'Morain, Segal, Levi, Elemental diet as primary treatment of acute Crohn's disease, BMJ, 288, pp. 1859-1862, (1984)
[3] Okada, Yao, Yamamoto, Et al., Controlled trial comparing an elemental diet with prednisolone in the treatment of active Crohn's disease, Hepatogastroenterology, 37, pp. 72-80, (1990)
[4] Seidman, Lohoues, Turgeon, Et al., Elemental diet versus prednisolone as initial therapy in Crohn's disease. Early and long term results, Gastroenterology, 100, (1991)
[5] Gorard, Hunt, Payne-James, Et al., Initial response and subsequent course of Crohn's disease treated with elemental diet or prednisolone, Gut, 34, pp. 1198-1202, (1993)
[6] Middleton, Riordan, Hunter, Comparison of elemental and peptide based diets in the treatment of acute Crohn's disease, Gut, 32 A, (1991)
[7] Giaffer, North, Holdsworth, Controlled trial of polymeric versus elemental diet in treatment of active Crohn's disease, Lancet, 335, pp. 816-819, (1990)
[8] Rigaud, Cosnes, Le Quintrec, Et al., Controlled trial comparing two types of enteral nutrition in treatment of active Crohn's disease: elemental versus polymeric diet, Gut, 32, pp. 1492-1497, (1991)
[9] Raouf, Hildrey, Daniel, Et al., Enteral feeding as sole treatment for Crohn's disease: controlled trial of whole protein v. amino acid based feed and a case study of dietarychallenge, Gut, 32, pp. 702-707, (1991)
[10] Park, Galloway, Booth, Et al., Double blind controlled trial of elemental and polymeric diets as primary therapy in active Crohn's disease, Eur J Gastroenterol Hepatol, 3, pp. 483-490, (1991)

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