INHERITANCE OF MHC CLASS-II GENES IN IDDM STUDIED IN POPULATION-BASED AFFECTED AND CONTROL FAMILIES

被引:18
作者
KOCKUM, I
WASSMUTH, R
HOLMBERG, E
MICHELSEN, B
LERNMARK, A
机构
[1] UNIV WASHINGTON, DEPT MED, RH WILLIAMS LAB, SEATTLE, WA USA
[2] LUND UNIV, WALLENBERG LAB, S-22101 LUND, SWEDEN
[3] UNIV ERLANGEN NURNBERG, MED KLIN 3, ERLANGEN, GERMANY
[4] UMEA UNIV, DEPT PEDIAT, UMEA, SWEDEN
[5] HAGEDORN RES LAB, GENTOFTE, DENMARK
关键词
TRANSMISSION RATES; NONINHERITED MATERNAL HAPLOTYPES; NONINHERITED PATERNAL HAPLOTYPES; HLA-DR; HLA-DQ;
D O I
10.1007/s001250050223
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p < 0.025) and DQB1*0302 (p < 0.01) from both parents to the index patient. There was an increased transmission of DQB1*0302 (p < 0.03) from the mothers only. The non-inherited maternal haplotypes showed a significantly decreased frequency (p < 0.01) of positively associated haplotypes (DR4-DQA1* 0301-DQB1*0302, DR3-DQA1*0501-DQB1*0201) compared to all parental haplotypes in the control families. In the control families neither transmission rates nor frequencies of non-inherited haplotypes differed from those expected in the control families. In conclusion, the observed reduction of IDDM-positively associated haplotypes in patient non-inherited maternal haplotypes, but not in non-inherited paternal haplotypes, suggests that tolerance during fetal life to maternal non-inherited HLA molecules may be important to diabetes development.
引用
收藏
页码:1105 / 1112
页数:8
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