THE CLINICALLY TESTED N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST MEMANTINE BLOCKS AND REVERSES THERMAL HYPERALGESIA IN A RAT MODEL OF PAINFUL MONONEUROPATHY

被引：66

作者：

EISENBERG, E

LACROSS, S

STRASSMAN, AM

机构：

[1] HARVARD UNIV,SCH MED,DEPT NEUROBIOL,BOSTON,MA 02115

[2] SPAULDING REHABIL HOSP,PAIN PROGRAM,BOSTON,MA 02114

[3] MASSACHUSETTS GEN HOSP,DEPT NEUROL,PAIN PHYSIOL LAB,BOSTON,MA 02129

来源：

NEUROSCIENCE LETTERS | 1995年 / 187卷 / 01期

关键词：

EXCITATORY AMINO ACID; GLUTAMATE; CHRONIC CONSTRICTIVE INJURY; SCIATIC NERVE;

D O I：

10.1016/0304-3940(95)11326-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study tested the prophylactic and therapeutic efficacy of memantine (1-amino-3,5-dimethyl-amandate), a clinically tested N-methyl-D-aspartate (NMDA) antagonist on thermal hyperalgesia in a rat model of painful mononeuropathy. Persistent hyperalgesia induced by chronic constrictive injury (CCI) to the sciatic nerve was significantly reduced for up to 14 days by prophylactic administration of memantine (3.0 mg/kg) via i.p implanted osmotic micropumps for a period of 7 days. Therapeutic i.p injections of memantine (10 mg/kg) given on post-injury days 7 and 14 completely reversed existing hyperalgesia for a short period of 1 h. These results provide evidence that memantine produces long-term prophylactic and short-term therapeutic effects on thermal hyperalgesia in a model of painful mononeuropathy.

引用

页码：17 / 20

页数：4

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