CLINICAL EXPERIENCE WITH HYPERPARATHYROIDISM IN SIXTY PATIENTS FIFTY-ONE OF THEM HAVING UROLITHIASIS

A series of 60 patients with histologically proven hyperparathyroidism, 51 of them having urolithiasis, is reported. In 57 of the patients surgical exploration was positive, and in 3 the diagnosis was confirmed at post-mortem examination. In an additional 8 patients parathyroid exploration was thus far negative. Application of classical clinical-biochemical criteria was successful in the establishment of the diagnosis in the greater majority of the cases of urolithiasis associated with hyperparathyroidism. The value of prolonged intensive clinical-biochemical follow-up in the diagnosis of hyperparathyroidism, enabling the establishment of the biochemical triad is pointed out. Prolonged clinical-biochemical follow-up after initially successful parathyroid surgery is important for the detection of recurrence of hyperparathyroidism. Uric acid lithiasis occurring in patients with hyperparathyroidism, both pre-operatively and following successful parathyroid surgery, may complicate the diagnosis. © 1968 S. Karger AG, Basel.