UNBALANCED TRANSMETHYLATION AND THE PERTURBATION OF THE DIFFERENTIATED STATE LEADING TO CANCER

被引：41

作者：

HOFFMAN, RM

机构：

[1] Laboratory of Cancer Biology, Department of Pediatrics, University of California, School of Medicine, La Jolla, California, 92093, San Diego

来源：

BIOESSAYS | 1990年 / 12卷 / 04期

关键词：

D O I：

10.1002/bies.950120404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is proposed that the perturbation of the differentiated state in cancer is related to alterations in DNA methylation as well as to alterations in methylation of other cellular molecules, leading to an imbalance in global cellular methylation. It is hypothesized that the global imbalance in methylation is reflected in the enhanced levels of transmethylation seen in many cancer cell types as well as in a number of undermethylated molecules. Copyright © 1990 Cambridge University Press

引用

页码：163 / 166

页数：4

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