EFFECT OF BETA-ADRENERGIC-RECEPTOR BLOCKING-DRUGS ON CEREBRAL BLOOD-FLOW

1 Cerebral blood flow (CBF) was measured by the 133xenon inhalation method in 33 newly‐diagnosed hypertensive patients prior to commencing therapy. 2 Blood pressure was treated by using a varying sequence of four different drugs, namely labetalol, metoprolol, oxprenolol and sotalol, each of which is a beta‐adrenergic receptor blocking agent, but with differing additional properties. 3 CBF measurements were repeated when blood pressure was controlled. No significant change in CBF was found with any of the four drugs, in contrast to the fall which has been reported when drugs of this type are administered acutely. 1979 The British Pharmacological Society