MUSCLE-RELAXATION RATE, FIBER-TYPE COMPOSITION AND ENERGY TURNOVER IN HYPER-THYROID AND HYPO-THYROID PATIENTS

被引:149
作者
WILES, CM [1 ]
YOUNG, A [1 ]
JONES, DA [1 ]
EDWARDS, RHT [1 ]
机构
[1] UNIV COLL HOSP LONDON, SCH MED, RAYNE INST, DEPT HUMAN METAB, LONDON WC1E 6JJ, ENGLAND
关键词
D O I
10.1042/cs0570375
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Quadriceps strength, relaxation rate, fibre-type composition and energy-turnover rate during a submaximal contraction have been measured in hypo- and hyper-thyroid patients and compared with findings in normal subjects. Six out of eight hypothyroid patients had normal strength whereas four out of five hyperthyroid patients were weak. Relaxation rate was decreased in all the hypothyroid patients but increased in only three out of five hyperthyroid patients. In hypothyroidism there was a marked reduction in the percentage contributed by type II fibres to muscle cross-section, partly due to type II atrophy but also due to a decrease in the relative frequency of type II fibres. In hyperthyroidism both fibre types tended to atrophy. The rate of ATP turnover during submaximal contraction held to fatigue was reduced in hypothyroidism. This was probably due to decreased ATP utilization rather than an impaired supply of energy-supplying substrates. In hyperthyroidism the rate of ATP turnover was increased. Altered relaxation rate and ATP-turnover rate may be explained on the basis of changes in myosin ATPase activity with thyroid status. Changes in muscle-fibre-type composition, as determined histochemically, could not per see account for the functional abnormalities.
引用
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页码:375 / 384
页数:10
相关论文
共 28 条
[1]  
ASH ASF, 1972, J PHYSIOL-LONDON, V224, P1
[2]  
BOLSTAD G, 1975, ACTA PHYSIOL SCAND, V95, pA73
[3]   DYNAMIC PROPERTIES OF MAMMALIAN SKELETAL-MUSCLES [J].
CLOSE, RI .
PHYSIOLOGICAL REVIEWS, 1972, 52 (01) :129-+
[4]   EFFECT OF HYPERTHYROIDISM ON SARCOPLASMIC-RETICULUM AND MYOSIN ATPASE OF DOG HEARTS [J].
CONWAY, G ;
HEAZLITT, RA ;
FOWLER, NO ;
GABEL, M ;
GREEN, S .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1976, 8 (01) :39-+
[5]   THYROID-HORMONES CONTROL LYSOSOMAL ENZYME-ACTIVITIES IN LIVER AND SKELETAL-MUSCLE [J].
DEMARTINO, GN ;
GOLDBERG, AL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (03) :1369-1373
[6]  
DUBOWITZ V, 1973, MUSCLE BIOPSY MODERN, P99
[7]   HUMAN SKELETAL-MUSCLE FUNCTION - DESCRIPTION OF TESTS AND NORMAL VALUES [J].
EDWARDS, RHT ;
YOUNG, A ;
HOSKING, GP ;
JONES, DA .
CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1977, 52 (03) :283-290
[8]   HEAT PRODUCTION AND CHEMICAL CHANGES DURING ISOMETRIC CONTRACTIONS OF HUMAN QUADRICEPS MUSCLE [J].
EDWARDS, RHT ;
HILL, DK ;
JONES, DA .
JOURNAL OF PHYSIOLOGY-LONDON, 1975, 251 (02) :303-315
[9]   METABOLIC CHANGES ASSOCIATED WITH SLOWING OF RELAXATION IN FATIGUED MOUSE MUSCLE [J].
EDWARDS, RHT ;
HILL, DK ;
JONES, DA .
JOURNAL OF PHYSIOLOGY-LONDON, 1975, 251 (02) :287-301
[10]  
EDWARDS RHT, 1975, LANCET, V1, P736