ERYTHROID COLONY GROWTH FROM PERIPHERAL-BLOOD AND BONE-MARROW IN POLYCYTHEMIA

被引:19
作者
MASTERS, GS
BAINES, P
JACOBS, A
机构
[1] Department of Haematology, University Hospital of Wales, Cardiff CF4 4XW, Heath Park
关键词
D O I
10.1136/jcp.43.11.937
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Erythroid colony growth in the presence and absence of erythropoietin was compared in 23 patients with primary proliferative polycythaemia (PPP), nine with idiopathic erythrocytosis, 10 with secondary polycythaemia, 15 with pseudopolycythaemia and in 76 normal subjects. Erythroid colonies growing without erythropoietin stimulation (endogenous erythroid colonies) from peripheral blood (BFU-E) were found in 20 of 22 patients with PPP and in two of seven with idiopathic erythrocytosis. None was found in secondary polycythaemia, pseudopolycythaemia, or in normal subjects. Small numbers of endogenous colony forming units-erythroid (CFU-E) (though not BFU-E) were cultured from the bone marrow of three of 24 normal subjects, suggesting that peripheral blood cultures provide a more specific indicator of clonal erythropoiesis. Peripheral blood endogenous erythroid colony growth is an effective and convenient means of distinguishing patients with clonal erythrocytosis and may be of particular value when iron deficiency obscures the diagnosis of PPP on conventional criteria.
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页码:937 / 941
页数:5
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