SOLID-STATE STUDIES ON STIRIPENTOL - A NOVEL ANTICONVULSANT DRUG

被引：7

作者：

CEOLIN, R

DUGUE, J

ROULAND, JC

RALAMBOSOA, C

LEPAGE, F

机构：

[1] FAC SCI PHARMACEUT & BIOL PARIS,CNRS,URA 200,CHIM MINERAL STRUCT LAB,4 AVE OBSERV,F-75270 PARIS 06,FRANCE

[2] FAC PHARM TOURS,CHIM PHYS LAB,F-37042 TOURS,FRANCE

[3] ZAC MERCIERES,CTR RECH CHEM ARMANCOURT,BIOCODEX LAB,F-60200 COMPIEGNE,FRANCE

[4] FAC MED & PHARM BESANCON,CHIM MINERALE LAB,F-25030 BESANCON,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 74卷 / 01期

关键词：

STIRIPENTOL; ANTIEPILEPTIC; RACEMATE COMPOUND; GLASS TRANSITION; SOLID STATE; X-RAY POWDER DIFFRACTION; DIFFERENTIAL SCANNING CALORIMETRY; INFRARED SPECTROMETRY;

D O I：

10.1016/0378-5173(91)90410-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Stiripentol, which exhibits antiepileptic properties is the E(+/-) 4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol. Solid state data obtained by means of X-ray powder diffractometry, differential scanning calorimetry, infrared spectrometry and solubility studies are given for quality control of the raw material. Stiripentol is an example of a racemate compound that easily forms persistent glasses whose thermodynamic properties are described and compared to those of the corresponding crystalline material.

引用

页码：77 / 82

页数：6

共 10 条

[1]

JACQUES J, 1981, ENANTIOMERS RACEMATE, P94

[2]

LIN HS, 1984, METABOLISM ANTIEPILE, P199

[3] THE STRUCTURE OF STIRIPENTOL - 4,4-DIMETHYL-1-(3,4-METHYLENEDIOXYPHENYL)-1-PENTEN-3-OL - A NOVEL ANTIEPILEPTIC DRUG [J].