INVIVO CELLULAR TROPISM OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-II (HTLV-II)

被引:108
作者
IJICHI, S [1 ]
RAMUNDO, MB [1 ]
TAKAHASHI, H [1 ]
HALL, WW [1 ]
机构
[1] N SHORE UNIV HOSP,CORNELL UNIV MED COLL,DIV INFECT DIS,300 COMMUNITY DR,MANHASSET,NY 11030
关键词
D O I
10.1084/jem.176.1.293
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To investigate the in vivo cellular tropism of human T cell leukemia virus type II (HTLV-II), subpopulations of fresh peripheral blood mononuclear cells from infected individuals were isolated and analyzed by polymerase chain reaction for the presence of provirus. In eight of nine patients, HTLV-II was detected exclusively in the CD8+ T lymphocyte population. In the remaining patient, provirus was also detected in CD4+ T lymphocytes. Provirus was not detected in B lymphocytes or monocytes of any patient. These results suggest that in vivo HTLV-II has a preferential, and perhaps in some cases, an exclusive tropism for CD8+ T lymphocytes. The findings contrast sharply with those on HTLV-I where there is a preferential tropism for CD4+ T lymphocytes. Although HTLV-II infection has not been consistently associated with any lymphoproliferative disorders, the results suggest that if these occur, they may be different from those known to be associated with HTLV-I.
引用
收藏
页码:293 / 296
页数:4
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